Homeostasis
Sensors, a control center and effectors hold a regulated variable near a set point, mostly by negative feedback.
Your body holds dozens of variables inside narrow ranges: core temperature, blood pressure, blood glucose, the pH and salt content of your blood. Each one is held the same way. A sensory receptor detects the variable, a control center compares it with a set point, and effectors push it back. Because the correction opposes the change, this is negative feedback, and it is how almost all regulation works.
Watch for it everywhere. When you stand up quickly and blood pools in your legs, pressure sensors in your arteries fire less, your brainstem raises heart rate and tightens arterioles, and your blood pressure recovers within seconds. The same loop, with different parts, runs your thermostat, your breathing and your kidneys. Positive feedback, which amplifies a change, is rare and always has an end point, such as childbirth or a clot sealing a wound.
Where it shows up
Chemistry and physics for physiology
Signals, repair and control
Integumentary system
Bone tissue
Nerves, reflexes and pathways
The autonomic nervous system
The endocrine system
- Hypothalamus and pituitary gland
- Thyroid and parathyroid glands
- The pancreas and blood glucose
- Adrenal glands
Blood
The cardiovascular system
- Cardiac output and its control
- Short-term blood pressure regulation
- Long-term blood pressure regulation
- Hypertension, heart failure and shock
Lymphatic and immune systems
The respiratory system
Metabolism and nutrition
The urinary system
Fluid, electrolyte and acid–base balance
- Body fluid compartments and water balance
- Electrolyte balance
- Regulating acid–base balance
- Acid–base disorders and compensation